ZUBEN E SAUNA : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (56)
Les plus populaires
Liste
- Liste
- Tableau

1

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections

Sauna, Zuben E., Shukla, Suneet, Ambudkar, Suresh V.

Journal:

Molecular BioSystems

Année:

2005

Langue:

english

Fichier:

PDF, 469 KB

english, 2005

2

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity

Lagassé, H. A. Daniel, Hengel, Hartmut, Golding, Basil, Sauna, Zuben E.

Journal:

The AAPS Journal

Année:

2019

Langue:

english

Fichier:

PDF, 2.52 MB

english, 2019

3

Exposing synonymous mutations

Hunt, Ryan C., Simhadri, Vijaya L., Iandoli, Matthew, Sauna, Zuben E., Kimchi-Sarfaty, Chava

Journal:

Trends in Genetics

Année:

2014

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2014

4

Understanding the contribution of synonymous mutations to human disease

Sauna, Zuben E., Kimchi-Sarfaty, Chava

Journal:

Nature Reviews Genetics

Année:

2011

Langue:

english

Fichier:

PDF, 621 KB

english, 2011

5

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

Chung-Jung Tsai, Zuben E. Sauna, Chava Kimchi-Sarfaty, Suresh V. Ambudkar, Michael M. Gottesman, Ruth Nussinov

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 597 KB

english, 2008

6

Detection of intracellular ADAMTS13, a secreted zinc-metalloprotease, via flow cytometry

S. Geetha, Courtni E. Allen, Ryan C. Hunt, Elizabeth Plum, Susan Garfield, Scott L. Friedman, Kenji Soejima, Zuben E. Sauna, Chava Kimchi-Sarfaty

Journal:

Cytometry Part A

Année:

2009

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2009

7

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

Suneet Shukla, Zuben E. Sauna, Rajendra Prasad, Suresh V. Ambudkar

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 824 KB

english, 2004

8

TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity

Yogurtcu, Osman N., Sauna, Zuben E., McGill, Joseph R., Tegenge, Million A., Yang, Hong

Journal:

The AAPS Journal

Année:

2019

Langue:

english

Fichier:

PDF, 3.18 MB

english, 2019

9

Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis

Xiao, Jerry, McGill, Joseph R., Stanton, Kelly, Kassner, Joshua D., Choudhury, Sujata, Schlegel, Richard, Sauna, Zuben E., Pohlmann, Paula R., Agarwal, Seema

Journal:

Année:

2020

Fichier:

PDF, 1.75 MB

2020

10

ChemInform Abstract: Synthesis and Analysis of Polyethylene Glycol Linked P-Glycoprotein-Specific Homodimers Based on (-)-Stipiamide.

Merritt B. Andrus, Timothy M. Turner, Emily P. Updegraff, Zuben E. Sauna, Suresh V. Ambudkar

Journal:

Année:

2001

Fichier:

PDF, 29 KB

2001

11

What does a Common Channel for Electrolytes and Non-electrolytes in the Sperm Mean?

V SITARAMAM, ZUBEN E SAUNA

Journal:

Journal of Theoretical Biology

Année:

2000

Langue:

english

Fichier:

PDF, 155 KB

english, 2000

12

Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (−)-stipiamide

Merritt B Andrus, Timothy M Turner, Emily P Updegraff, Zuben E Sauna, Suresh V Ambudkar

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 77 KB

english, 2001

13

Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (−)-stipiamide

Merritt B Andrus, Timothy M Turner, Zuben E Sauna, Suresh V Ambudkar

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 155 KB

english, 2000

14

Genomics and the mechanism of P-glycoprotein (ABCB1)

Zuben E. Sauna, In-Wha Kim, Suresh V. Ambudkar

Journal:

Journal of Bioenergetics and Biomembranes

Année:

2007

Langue:

english

Fichier:

PDF, 180 KB

english, 2007

15

P-glycoprotein: from genomics to mechanism

Ambudkar, Suresh V, Kimchi-Sarfaty, Chava, Sauna, Zuben E, Gottesman, Michael M

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 474 KB

english, 2003

16

The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein

Zuben E. Sauna, Melissa M. Smith, Marianna Müller, Kathleen M. Kerr, Suresh V. Ambudkar

Journal:

Journal of Bioenergetics and Biomembranes

Année:

2001

Langue:

english

Fichier:

PDF, 372 KB

english, 2001

17

Volume regulation of spermatozoa by quinine-sensitive channels

Satish B. Kulkarni, Zuben E. Sauna, V. Somlata, V. Sitaramam

Journal:

Molecular Reproduction and Development

Année:

1997

Langue:

english

Fichier:

PDF, 255 KB

english, 1997

18

Pharmacogenetics and the immunogenicity of protein therapeutics

Yanover, Chen, Jain, Nisha, Pierce, Glenn, Howard, Tom E, Sauna, Zuben E

Journal:

Nature Biotechnology

Année:

2011

Langue:

english

Fichier:

PDF, 545 KB

english, 2011

19

Plasma derivatives: New products and new approaches

Zuben E. Sauna, Gouri Shankar Pandey, Nisha Jain, Ifthekar Mahmood, Chava Kimchi-Sarfaty, Basil Golding

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 342 KB

english, 2012

20

The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)

Suresh V. Ambudkar, In-Wha Kim, Zuben E. Sauna

Journal:

European Journal of Pharmaceutical Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 372 KB

english, 2006

21

The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

Suresh V. Ambudkar, In-Wha Kim, Di Xia, Zuben E. Sauna

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 363 KB

english, 2006

22

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)

Suresh V. Ambudkar, Zuben E. Sauna, Michael M. Gottesman, Gergely Szakacs

Journal:

Trends in Pharmacological Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2005

23

The Conserved Tyrosine Residues 401 and 1044 in ATP Sites of Human P-Glycoprotein Are Critical for ATP Binding and Hydrolysis: Evidence for a Conserved Subdomain, the A-Loop in the ATP-Binding Cassette †

Kim, In-Wha, Peng, Xiang-Hong, Sauna, Zuben E., FitzGerald, Peter C., Xia, Di, Müller, Marianna, Nandigama, Krishnamachary, Ambudkar, Suresh V.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 384 KB

english, 2006

24

Biochemical Basis of Polyvalency as a Strategy for Enhancing the Efficacy of P-Glycoprotein (ABCB1) Modulators: Stipiamide Homodimers Separated with Defined-Length Spacers Reverse Drug Efflux with Greater Efficacy

Sauna, Zuben E., Andrus, Merritt B., Turner, Timothy M., Ambudkar, Suresh V.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 358 KB

english, 2004

25

Mutational Analysis of ABCG2: Role of the GXXXG Motif

Polgar, Orsolya, Robey, Robert W., Morisaki, Kuniaki, Dean, Michael, Michejda, Christopher, Sauna, Zuben E., Ambudkar, Suresh V., Tarasova, Nadya, Bates, Susan E.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 258 KB

english, 2004

26

Building better drugs: developing and regulating engineered therapeutic proteins

Kimchi-Sarfaty, Chava, Schiller, Tal, Hamasaki-Katagiri, Nobuko, Khan, Mansoor A., Yanover, Chen, Sauna, Zuben E.

Journal:

Trends in Pharmacological Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 943 KB

english, 2013

27

Mapping Conformational Changes Associated with the Catalytic Cycle of Human P-Glycoprotein (ABCB1)

Bhatnagar, Jaya, Sim, Hong-May, Georgieva, Elka, Kapoor, Khyati, Chufan, Eduardo, Ohnuma, Shinobu, Borbat, Peter P., Freed, Jack H., Sauna, Zuben E., Ambudkar, Suresh V.

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 51 KB

english, 2012

28

Complete Inhibition of the Pdr5p Multidrug Efflux Pump ATPase Activity by Its Transport Substrate Clotrimazole Suggests that GTP as Well as ATP May Be Used as an Energy Source †

Golin, John, Kon, Zachary N., Wu, Chung-Pu, Martello, Justin, Hanson, Leanne, Supernavage, Sherry, Ambudkar, Suresh V., Sauna, Zuben E.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 292 KB

english, 2007

29

Inhibition of Multidrug Resistance-Linked P-Glycoprotein (ABCB1) Function by 5′-Fluorosulfonylbenzoyl 5′-Adenosine: Evidence for an ATP Analogue That Interacts with Both Drug-Substrate-and Nucleotide-Binding Sites

Ohnuma, Shinobu, Chufan, Eduardo, Nandigama, Krishnamachary, Jenkins, Lisa M. Miller, Durell, Stewart R., Appella, Ettore, Sauna, Zuben E., Ambudkar, Suresh V.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 3.10 MB

english, 2011

30

The Signaling Interface of the Yeast Multidrug Transporter Pdr5 Adopts a Cis Conformation, and There Are Functional Overlap and Equivalence of the Deviant and Canonical Q-Loop Residues

Ananthaswamy, Neeti, Rutledge, Robert, Sauna, Zuben E., Ambudkar, Suresh V., Dine, Elliot, Nelson, Emily, Xia, Di, Golin, John

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 4.75 MB

english, 2010

31

Importance of the Conserved Walker B Glutamate Residues, 556 and 1201, for the Completion of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein (ABCB1)

Sauna, Zuben E., Müller, Marianna, Peng, Xiang-Hong, Ambudkar, Suresh V.

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 230 KB

english, 2002

32

Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein: Evidence for Formation of the E·S Reaction Intermediate with ATP-γ-S, a Nonhydrolyzable Analogue of ATP †

Sauna, Zuben E., Kim, In-Wha, Nandigama, Krishnamachary, Kopp, Stephan, Chiba, Peter, Ambudkar, Suresh V.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 515 KB

english, 2007

33

Pharmacogenetics and the Immunogenicity of Protein Therapeutics

Pandey, Gouri S., Sauna, Zuben E.

Journal:

Journal of Interferon & Cytokine Research

Année:

2014

Langue:

english

Fichier:

PDF, 224 KB

english, 2014

34

Fc fusion as a platform technology: potential for modulating immunogenicity

Levin, Ditza, Golding, Basil, Strome, Scott E., Sauna, Zuben E.

Journal:

Trends in Biotechnology

Année:

2015

Langue:

english

Fichier:

PDF, 1009 KB

english, 2015

35

Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)

Hershko, Klilah, Simhadri, Vijaya L., Blaisdell, Adam, Hunt, Ryan C., Newell, Jordan, Tseng, Sandra C., Hershko, Alon Y., Choi, Jae Won, Sauna, Zuben E., Wu, Andrew, Bram, Richard J., Komar, Anton A.,

Journal:

Journal of Biological Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.61 MB

english, 2012

36

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

Pandey, Gouri Shankar, Tseng, Sandra C., Howard, Tom E., Sauna, Zuben E.

Journal:

BioMed Research International

Année:

2013

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2013

37

Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment

Pandey, Gouri Shankar, Yanover, Chen, Howard, Tom E., Sauna, Zuben E., Nielsen, Morten

Journal:

PLoS Computational Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2013

38

Personalized approaches to the treatment of hemophilia A and B

Simhadri, Vijaya L, Banerjee, Aditi Sengupta, Simon, Jonathan, Kimchi-Sarfaty, Chava, Sauna, Zuben E

Journal:

Personalized Medicine

Année:

2015

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2015

39

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

Hoinka, Jan, Berezhnoy, Alexey, Dao, Phuong, Sauna, Zuben E., Gilboa, Eli, Przytycka, Teresa M.

Journal:

Nucleic Acids Research

Année:

2015

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2015

40

The sounds of silence: synonymous mutations affect function

Sauna, Zuben E, Kimchi-Sarfaty, Chava, Ambudkar, Suresh V, Gottesman, Michael M

Journal:

Pharmacogenomics

Année:

2007

Langue:

english

Fichier:

PDF, 510 KB

english, 2007

41

[Topics in Medicinal Chemistry] Protein Therapeutics Volume 21 || Immunogenicity Lessons Learned from the Clinical Development of Vatreptacog Alfa, A Recombinant Activated Factor VII Analog, in Hemophilia with Inhibitors

Sauna, Zuben E., Kimchi-Sarfaty, Chava

Année:

2017

Langue:

english

Fichier:

PDF, 900 KB

english, 2017

42

Immunogenicity assessment during the development of protein therapeutics

Rosenberg, Amy S., Sauna, Zuben E.

Journal:

Journal of Pharmacy and Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 333 KB

english, 2017

43

Evaluating and Mitigating the Immunogenicity of Therapeutic Proteins

Sauna, Zuben E., Lagassé, Daniel, Pedras-Vasconcelos, Joao, Golding, Basil, Rosenberg, Amy S.

Journal:

Trends in Biotechnology

Année:

2018

Langue:

english

Fichier:

PDF, 2.68 MB

english, 2018

44

Prevalence of Pre-existing Antibodies to CRISPR-associated Nuclease Cas9 in the US Population

Simhadri, Vijaya L., McGill, Joseph, McMahon, Shane, Wang, Junxia, Jiang, Haiyan, Sauna, Zuben E.

Journal:

Molecular Therapy — Methods & Clinical Development

Année:

2018

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2018

45

Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins

Zichel, Ran, Chearwae, Wanida, Pandey, Gouri Shankar, Golding, Basil, Sauna, Zuben E., Rossi, John J.

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 918 KB

english, 2012

46

Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

Sarachana, Tewarit, Dahiya, Neetu, Simhadri, Vijaya L., Pandey, Gouri Shankar, Saini, Surbhi, Guelcher, Christine, Guerrera, Michael F., Kimchi-Sarfaty, Chava, Sauna, Zuben E., Atreya, Chintamani D.,

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 739 KB

english, 2015

47

Recent advances in (therapeutic protein) drug development

Lagassé, H.A. Daniel, Alexaki, Aikaterini, Simhadri, Vijaya L., Katagiri, Nobuko H., Jankowski, Wojciech, Sauna, Zuben E., Kimchi-Sarfaty, Chava

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2017

48

Translational and transcriptional responses in human primary hepatocytes under hypoxia

Hettiarachchi, Gaya K, Katneni, Upendra K, Hunt, Ryan C, Kames, Jacob M, Athey, John C, Bar, Haim, Sauna, Zuben E, McGill, Joseph R, Ibla, Juan C, Kimchi-Sarfaty, Chava

Journal:

American Journal of Physiology - Gastrointestinal and Liver Physiology

Année:

2019

Langue:

english

Fichier:

PDF, 3.36 MB

english, 2019

49

Clinical manifestation of hemophilia A in the absence of mutations in the F8 gene that encodes FVIII: role of microRNAs

Jankowska, Katarzyna I., McGill, Joseph, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Atreya, Chintamani D., Sauna, Zuben E.

Journal:

Transfusion (Wiley)

Année:

2019

Langue:

english

Fichier:

PDF, 6.89 MB

english, 2019

50

SampPick: Selection of a Cohort of Subjects Matching a Population HLA Distribution

McGill, Joseph R., Yogurtcu, Osman N., Verthelyi, Daniela, Yang, Hong, Sauna, Zuben E.

Journal:

Frontiers in Immunology

Année:

2019

Langue:

english

Fichier:

PDF, 3.22 MB

english, 2019